Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 14/20 | 0.56 |
| ▸ | JAK2 | O60674 | 13/20 | 0.56 |
| ▸ | CFTR | P13569 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.35 |
| ▸ | SGK1 | O00141 | 1/20 | 0.35 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184536 | 0.89 | JAK3 (0.47) | JAK3JAK2 | |
| SCHEMBL20184377 | 0.87 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184679 | 0.86 | JAK3 (0.56) | JAK3JAK2MAP4K1 | |
| SCHEMBL20184408 | 0.86 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184605 | 0.82 | JAK3 (0.59) | JAK3JAK2 | |
| SCHEMBL20184581 | 0.82 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184434 | 0.81 | JAK3 (0.74) | JAK3JAK2 | |
| SCHEMBL20184672 | 0.81 | JAK2 (0.54) | JAK3JAK2SGK1CAMKK2 | |
| SCHEMBL20184489 | 0.80 | JAK2 (0.51) | JAK3JAK2SGK1CAMKK2 | |
| SCHEMBL20184527 | 0.80 | JAK2 (0.49) | JAK3JAK2SGK1CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |