Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 17/20 | 0.47 |
| ▸ | JAK2 | O60674 | 16/20 | 0.47 |
| ▸ | TYMS | P04818 | 2/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184515 | 0.89 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184377 | 0.85 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184408 | 0.84 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184564 | 0.84 | JAK3 (0.63) | JAK3JAK2 | |
| SCHEMBL20184679 | 0.84 | JAK3 (0.56) | JAK3JAK2 | |
| SCHEMBL20184527 | 0.80 | JAK2 (0.49) | JAK3JAK2 | |
| SCHEMBL20184581 | 0.79 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184673 | 0.79 | JAK2 (0.53) | JAK3JAK2 | |
| SCHEMBL20184672 | 0.78 | JAK2 (0.54) | JAK3JAK2 | |
| SCHEMBL20184548 | 0.78 | JAK3 (0.53) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |