Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.53 |
| ▸ | JAK2 | O60674 | 7/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | DHODH | Q02127 | 3/20 | 0.39 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.39 |
| ▸ | SGK1 | O00141 | 1/20 | 0.39 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.39 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184548 | 0.88 | JAK3 (0.53) | JAK3JAK2CHUKDHODHSGK1 | |
| SCHEMBL20184551 | 0.88 | JAK3 (0.53) | JAK3JAK2DHODHKMOPIN1 | |
| SCHEMBL20184525 | 0.87 | JAK2 (0.49) | JAK3JAK2CHUKSGK1CAMKK2 | |
| SCHEMBL20184478 | 0.87 | JAK2 (0.53) | JAK3JAK2DHODHDCLRE1BKMO | |
| SCHEMBL20184581 | 0.87 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184555 | 0.86 | HSP90AB1 (0.43) | JAK3JAK2CHUKHSP90AB1DHODH | |
| SCHEMBL20184417 | 0.86 | DYRK1A (0.45) | JAK3JAK2DHODH | |
| SCHEMBL20184489 | 0.85 | JAK2 (0.51) | JAK3JAK2DHODHSGK1CAMKK2 | |
| SCHEMBL20184518 | 0.85 | PRKAB2 (0.48) | JAK3JAK2DHODHPIN1 | |
| SCHEMBL20184593 | 0.85 | GPR84 (0.48) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |