Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 18/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184444 | 0.87 | JAK3 (0.59) | JAK3JAK1 | |
| SCHEMBL20184529 | 0.86 | JAK3 (0.59) | JAK3JAK1 | |
| SCHEMBL16245166 | 0.83 | JAK3 (0.58) | JAK3JAK1 | |
| SCHEMBL20184608 | 0.83 | JAK3 (0.77) | JAK3JAK1 | |
| SCHEMBL20184514 | 0.81 | JAK3 (0.61) | JAK3JAK1HSP90AB1 | |
| SCHEMBL20184355 | 0.81 | JAK3 (0.47) | JAK3JAK1HSP90AB1 | |
| SCHEMBL20184677 | 0.79 | F11 (0.43) | JAK3HSP90AB1 | |
| SCHEMBL20184329 | 0.79 | HSP90AB1 (0.46) | JAK3JAK1HSP90AB1 | |
| SCHEMBL20184524 | 0.78 | JAK3 (0.59) | JAK3JAK1 | |
| SCHEMBL20184360 | 0.77 | JAK3 (0.60) | JAK3JAK1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |