Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.46 |
| ▸ | CHUK | O15111 | 9/20 | 0.39 |
| ▸ | JAK2 | O60674 | 6/20 | 0.38 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | IKBKB | O14920 | 6/20 | 0.38 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYMS | P04818 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184677 | 0.87 | F11 (0.43) | HSP90AB1CHUKJAK2JAK3IKBKB | |
| SCHEMBL20184489 | 0.86 | JAK2 (0.51) | JAK2JAK3CAMKK2 | |
| SCHEMBL20184337 | 0.86 | JAK2 (0.43) | HSP90AB1CHUKJAK2JAK3IKBKB | |
| SCHEMBL20184527 | 0.86 | JAK2 (0.49) | HSP90AB1CHUKJAK2JAK3IKBKB | |
| SCHEMBL20184525 | 0.86 | JAK2 (0.49) | CHUKJAK2JAK3CAMKK2 | |
| SCHEMBL20184555 | 0.85 | HSP90AB1 (0.43) | HSP90AB1CHUKJAK2JAK3CAMKK2 | |
| SCHEMBL20184700 | 0.85 | JAK2 (0.40) | JAK2JAK3 | |
| SCHEMBL20184357 | 0.83 | CHUK (0.47) | CHUKJAK2JAK3CAMKK2TYMS | |
| SCHEMBL20184538 | 0.83 | JAK2 (0.39) | HSP90AB1JAK2JAK3CAMKK2 | |
| SCHEMBL20184582 | 0.83 | JAK2 (0.52) | HSP90AB1JAK2JAK3CAMKK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |