Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | PTPRA | P18433 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | F2R | P25116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184481 | 0.90 | CYP3A4 (0.48) | JAK3JAK1KDM4EALDH1A1POLB | |
| SCHEMBL20184694 | 0.86 | JAK3 (0.47) | JAK3JAK1JAK2 | |
| SCHEMBL16245166 | 0.86 | JAK3 (0.58) | JAK3JAK1JAK2 | |
| SCHEMBL20184542 | 0.85 | JAK3 (0.48) | JAK3JAK1JAK2 | |
| SCHEMBL20184680 | 0.85 | JAK3 (0.49) | JAK3JAK1JAK2MEN1KMT2A | |
| SCHEMBL20184704 | 0.84 | JAK3 (0.59) | JAK3JAK1JAK2 | |
| SCHEMBL20184567 | 0.84 | JAK3 (0.58) | JAK3JAK1JAK2 | |
| SCHEMBL20184425 | 0.83 | JAK3 (0.59) | JAK3JAK1JAK2 | |
| SCHEMBL20184552 | 0.83 | JAK3 (0.51) | JAK3JAK1JAK2 | |
| SCHEMBL20184584 | 0.83 | JAK3 (0.59) | JAK3JAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |