Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 0.53 |
| ▸ | JAK2 | O60674 | 10/20 | 0.53 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SGK1 | O00141 | 1/20 | 0.37 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184551 | 0.89 | JAK3 (0.53) | JAK3JAK2DHODHMAPTSIRT5 | |
| SCHEMBL20184525 | 0.88 | JAK2 (0.49) | JAK3JAK2CHUKSGK1CAMKK2 | |
| SCHEMBL20184478 | 0.88 | JAK2 (0.53) | JAK3JAK2DHODH | |
| SCHEMBL20184599 | 0.88 | JAK3 (0.53) | JAK3JAK2CHUKDHODHSGK1 | |
| SCHEMBL20184581 | 0.88 | JAK3 (0.43) | JAK3JAK2 | |
| SCHEMBL20184417 | 0.87 | DYRK1A (0.45) | JAK3JAK2DHODHCHEK1 | |
| SCHEMBL20184489 | 0.86 | JAK2 (0.51) | JAK3JAK2DHODHSGK1CAMKK2 | |
| SCHEMBL20184527 | 0.86 | JAK2 (0.49) | JAK3JAK2IKBKBCHUKDHODH | |
| SCHEMBL20184518 | 0.86 | PRKAB2 (0.48) | JAK3JAK2DHODHMAPT | |
| SCHEMBL20184593 | 0.86 | GPR84 (0.48) | JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |