Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.53 |
| ▸ | JAK3 | P52333 | 5/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.47 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20184551 | 0.88 | JAK3 (0.53) | JAK2JAK3PIN1DHODHKMO | |
| SCHEMBL20184548 | 0.88 | JAK3 (0.53) | JAK2JAK3DHODH | |
| SCHEMBL20184525 | 0.87 | JAK2 (0.49) | JAK2JAK3 | |
| SCHEMBL20184599 | 0.87 | JAK3 (0.53) | JAK2JAK3PIN1DHODHDCLRE1B | |
| SCHEMBL20184581 | 0.87 | JAK3 (0.43) | JAK2JAK3 | |
| SCHEMBL20184700 | 0.86 | JAK2 (0.40) | JAK2JAK3DHODH | |
| SCHEMBL20184417 | 0.86 | DYRK1A (0.45) | JAK2JAK3PDE4BDHODH | |
| SCHEMBL20184489 | 0.85 | JAK2 (0.51) | JAK2JAK3DHODH | |
| SCHEMBL20184593 | 0.85 | GPR84 (0.48) | JAK2JAK3 | |
| SCHEMBL20184518 | 0.85 | PRKAB2 (0.48) | JAK2JAK3PIN1DHODHADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2788000-B1 | PYRROLOPYRIMIDINES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-05-30 | — | — | EP | claimed |