Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13061956 | 0.87 | AKR1C3 (0.53) | HSD17B10POLBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL983847 | 0.83 | HSD17B10 (0.65) | HSD17B10POLBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL27557248 | 0.83 | CYP3A4 (0.49) | GSK3BHSD17B10POLBAKR1C3AKR1C2 | |
| SCHEMBL2436724 | 0.81 | ALDH1A1 (0.54) | HSD17B10POLBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL30046118 | 0.81 | ALDH1A1 (0.54) | HSD17B10POLBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL8637464 | 0.81 | HSD17B10 (0.46) | GSK3BHSD17B10POLBAKR1C3AKR1C2 | |
| SCHEMBL1097958 | 0.81 | HSD17B10 (0.46) | GSK3BHSD17B10POLBAKR1C3AKR1C2 | |
| SCHEMBL26824456 | 0.81 | PLA2G2A (0.48) | HSD17B10POLBAKR1C3AKR1C2PTGS1 | |
| SCHEMBL13012120 | 0.79 | HSD17B10 (0.44) | GSK3BHSD17B10POLBAKR1C3AKR1C2 | |
| SCHEMBL13742193 | 0.78 | PPARG (0.47) | HSD17B10POLBHPGDKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107849054-B | NOTCH pathway signaling inhibitor compounds | 伊莱利利公司 | 2020-04-28 | — | — | CN | disclosed |
| US-10450317-B2 | Notch pathway signaling inhibitor compounds | ELI LILLY AND COMPANY (US) | 2019-10-22 | — | — | US | disclosed |
| US-10450317-B2 | Notch pathway signaling inhibitor compounds | ELI LILLY AND COMPANY (US) | 2019-10-22 | — | — | US | disclosed |
| EP-3319967-B1 | NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS | LILLY CO ELI (US) | 2019-05-22 | — | — | EP | disclosed |
| US-20180148456-A1 | NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS | AUDION THERAPEUTICS (NL) | 2018-05-31 | — | — | US | disclosed |
| US-20180148456-A1 | NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS | AUDION THERAPEUTICS (NL) | 2018-05-31 | — | — | US | disclosed |
| US-20180148456-A1 | NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS | AUDION THERAPEUTICS (NL) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10450317-B2 | Notch pathway signaling inhibitor compounds | NOTCH1, NOTCH2, NOTCH3 | GSK3B 78/4885HSD17B10 3191/4885POLB 4013/4885 |
| US-20180148456-A1 | NOTCH PATHWAY SIGNALING INHIBITOR COMPOUNDS | NOTCH1, NOTCH2, NOTCH3 | GSK3B 78/4885HSD17B10 3191/4885POLB 4013/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.