Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27557248 | 0.84 | CYP3A4 (0.49) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL983847 | 0.84 | HSD17B10 (0.65) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL30046118 | 0.83 | ALDH1A1 (0.54) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL26824456 | 0.83 | PLA2G2A (0.48) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL1097958 | 0.83 | HSD17B10 (0.46) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL2436724 | 0.83 | ALDH1A1 (0.54) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL13061956 | 0.81 | AKR1C3 (0.53) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL20185728 | 0.81 | GSK3B (0.46) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL13012120 | 0.80 | HSD17B10 (0.44) | HSD17B10POLBPTGS1AKR1C3AKR1C2 | |
| SCHEMBL13742193 | 0.79 | PPARG (0.47) | HSD17B10POLBHPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516257-B1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AG (DE) | 1998-08-05 | — | — | EP | disclosed |
| WO-1992021669-A1 | 2-PHENYLBENZO[B]FURANS AND THIOPHENES, METHODS OF PREPARING THEM AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-10 | — | — | WO | disclosed |
| EP-0516257-A1 | Phenylbenzo[b]furans and -thiophenes, procedures for their preparation, and pharmaceutical compositions containing the same | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-12-02 | — | — | EP | disclosed |