SCHEMBL201858

SCHEMBL201858

NC(=O)c1c(F)ccc(OCc2nccs2)c1F

nearest known ligand 0.56

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
BTK Q06187 3/20 0.38
KMT2A Q03164 3/20 0.38
BACE1 P56817 2/20 0.35
GRM5 P41594 1/20 0.35
ACACB O00763 1/20 0.35
MEN1 O00255 2/20 0.34
ALDH1A1 P00352 1/20 0.34
NPC1 O15118 2/20 0.34
RAB9A P51151 2/20 0.34
CTSA P10619 2/20 0.34
TNKS2 Q9H2K2 1/20 0.34
AOC3 Q16853 1/20 0.33
FFAR1 O14842 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL201928 0.81 NPC1 (0.38) BACE1NPC1RAB9ATNKS2FFAR1
SCHEMBL27738132 0.81 NPC1 (0.45) BTKKMT2AMEN1ALDH1A1NPC1
SCHEMBL3652832 0.79 TLR7 (0.37) MEN1NPC1RAB9A
SCHEMBL203215 0.79 ROCK2 (0.37) KMT2ANPC1RAB9ACTSATNKS2
SCHEMBL2705996 0.77 ROCK2 (0.40) KMT2AMEN1ALDH1A1NPC1RAB9A
SCHEMBL202084 0.77 SLC1A3 (0.41) ALDH1A1
SCHEMBL31609727 0.77 MAPK1 (0.46) KMT2AMEN1ALDH1A1NPC1RAB9A
SCHEMBL203974 0.77 SMN1; SMN2 (0.38) KMT2AMEN1ALDH1A1NPC1RAB9A
SCHEMBL2704600 0.77 FFAR1 (0.41) NPC1RAB9AFFAR1
SCHEMBL2705814 0.77 MAPT (0.38) KMT2AMEN1ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250179008-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. (US) 2025-06-05 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-20150191420-A1 ANTIBACTERIAL AGENTS TAXIS PHARMACEUTICALS, INC. 2015-07-09 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-8865736-B2 Antibacterial agents Biota Scientific Pty Ltd (AU) 2014-10-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20130072520-A2 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2013-03-21 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-20120122918-A1 ANTIBACTERIAL AGENTS BIOTA SCIENTIFIC MANAGEMENT PTY LTD (AU) 2012-05-17 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
US-8088791-B2 Antibacterial agents Biots Scientific Management Pty Ltd (AU) 2012-01-03 US disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
EP-1996180-B1 BENZAMIDE AND PYRIDYLAMIDE DERIVATIVES AS ANTIBACTERIAL AGENTS BIOTA EUROPE LTD (GB) 2011-08-03 EP disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
US-20100173933-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2010-07-08 US disclosed
WO-2007107758-A1 ANTIBACTERIAL AGENTS PROLYSIS LTD (GB) 2007-09-27 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120122918-A1 ANTIBACTERIAL AGENTS ALK, ROS1, ARG1 BTK 3094/4885KMT2A 380/4885BACE1 2803/4885
US-20130072520-A2 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 BTK 3221/4885KMT2A 1011/4885BACE1 2108/4885
US-20150191420-A1 ANTIBACTERIAL AGENTS ALK, ARG1, ROS1 BTK 3578/4885KMT2A 415/4885BACE1 2957/4885
US-20250179008-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 BTK 3221/4885KMT2A 1011/4885BACE1 2108/4885
US-20100173933-A1 ANTIBACTERIAL AGENTS ALK, ROS1, NOX1 BTK 3221/4885KMT2A 1011/4885BACE1 2108/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.