SCHEMBL20186980

SCHEMBL20186980

Cc1ccc(CS(=O)(=O)Nc2ccc(C#N)c(C(F)(F)F)c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 1/20 0.54
AR P10275 7/20 0.51
PLA2G7 Q13093 1/20 0.46
IMPDH2 P12268 1/20 0.46
PGR P06401 2/20 0.45
FFAR4 Q5NUL3 1/20 0.44
CNR2 P34972 1/20 0.44
CYP2C19 P33261 1/20 0.44
RORC P51449 1/20 0.44
ABCB11 O95342 1/20 0.44
ALB P02768 1/20 0.44
ADRA2C P18825 1/20 0.44
GHSR Q92847 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20187001 0.89 SLC22A12 (0.55) SLC22A12ARIMPDH2PGRCNR2
SCHEMBL20186971 0.88 SLC22A12 (0.54) SLC22A12ARIMPDH2PGRFFAR4
SCHEMBL20186995 0.88 SLC22A12 (0.54) SLC22A12ARPLA2G7IMPDH2PGR
SCHEMBL20186990 0.84 RORC (0.51) SLC22A12ARPLA2G7FFAR4CNR2
SCHEMBL20186964 0.84 IMPDH2 (0.50) SLC22A12ARIMPDH2PGRRORC
SCHEMBL20187005 0.81 SLC22A12 (0.54) SLC22A12PLA2G7IMPDH2
SCHEMBL20186979 0.81 IMPDH2 (0.48) SLC22A12IMPDH2PGRRORC
SCHEMBL20186969 0.81 IMPDH2 (0.48) SLC22A12IMPDH2PGRRORC
SCHEMBL20186961 0.81 FFAR4 (0.67) ARFFAR4RORC
SCHEMBL20186965 0.81 RORC (0.48) SLC22A12IMPDH2PGRRORC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10905120-B2 ABA receptor agonists that modulate transpiration THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2021-02-02 US disclosed
US-20180146666-A1 ABA RECEPTOR AGONISTS THAT MODULATE TRANSPIRATION THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2018-05-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10905120-B2 ABA receptor agonists that modulate transpiration ADORA2A, ADORA1, AAK1 SLC22A12 930/4885AR 1334/4885PLA2G7 1724/4885
US-20180146666-A1 ABA RECEPTOR AGONISTS THAT MODULATE TRANSPIRATION ADORA2A, ADORA1, AAK1 SLC22A12 930/4885AR 1334/4885PLA2G7 1724/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.