Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nifedipine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C known ✓ | Q13936 | 4/20 | 0.55 |
| ▸ | CACNA1F known ✓ | O60840 | 2/20 | 0.55 |
| ▸ | CACNA1D known ✓ | Q01668 | 2/20 | 0.55 |
| ▸ | CACNA1S known ✓ | Q13698 | 2/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.55 |
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.55 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.55 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.55 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.55 |
| ▸ | SCN1A | P35498 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10552872 | 0.79 | ADORA3 (0.76) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| SCHEMBL10276913 | 0.78 | RAB9A (0.54) | MAPTKMT2ALMNATSHRHPGD | |
| SCHEMBL10555442 | 0.75 | ADORA3 (0.79) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL3968 | 0.74 | ADORA3 (1.00) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL29349595 | 0.74 | ADORA3 (1.00) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL1172946 | 0.74 | ADORA3 (1.00) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL8851402 | 0.73 | ADORA3 (0.97) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL5694031 | 0.73 | ADORA3 (0.97) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL3858071 | 0.73 | ADORA3 (0.97) | ADORA3MAPTCYP1A2KMT2ACACNA1C | |
| Nifedipine SCHEMBL27076587 | 0.73 | ADORA3 (0.97) | ADORA3MAPTCYP1A2KMT2ACACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10454136-B2 | Polymer electrolyte, polymer electrolyte composition, battery, and electronic apparatus | SEIKO EPSON CORPORATION (JP) | 2019-10-22 | — | — | US | disclosed |
| US-10411298-B2 | Polyelectrolyte composition, polyelectrolyte, battery, and electronic apparatus | SEIKO EPSON CORPORATION (JP) | 2019-09-10 | — | — | US | disclosed |
| US-20180183098-A1 | POLYMER ELECTROLYTE, POLYMER ELECTROLYTE COMPOSITION, BATTERY, AND ELECTRONIC APPARATUS | SEIKO EPSON CORPORATION (JP) | 2018-06-28 | — | — | US | disclosed |
| US-20180151915-A1 | POLYELECTROLYTE COMPOSITION, POLYELECTROLYTE, BATTERY, AND ELECTRONIC APPARATUS | SEIKO EPSON CORPORATION (JP) | 2018-05-31 | — | — | US | disclosed |