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SCHEMBL20190609

SCHEMBL20190609

CC1(C)OB(c2cnc(OC3CC(F)(F)C3)c(F)c2)OC1(C)C

nearest known ligand 0.41

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ CYP1A2 P05177 1/20 0.41
▸ AAK1 Q2M2I8 1/20 0.40
▸ ROCK2 O75116 1/20 0.39
▸ ALPL P05186 1/20 0.33
▸ LPL P06858 1/20 0.33
▸ LIPG Q9Y5X9 1/20 0.33
▸ DGAT1 O75907 2/20 0.32
▸ PDGFRB P09619 1/20 0.32
▸ KDR P35968 1/20 0.32
▸ ROCK1 Q13464 1/20 0.31
▸ GSK3A P49840 1/20 0.30
▸ GSK3B P49841 1/20 0.30
▸ ACACB O00763 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20763262 0.86 ROCK2 (0.35) CYP1A2AAK1ROCK2ALPL
SCHEMBL22711845 0.84 AAK1 (0.38) AAK1ROCK2ALPLLPLLIPG
SCHEMBL22711847 0.79 AAK1 (0.42) AAK1ROCK2ALPLLPLLIPG
SCHEMBL251502 0.78 ALPL (0.45) AAK1ALPLLPLLIPGDGAT1
SCHEMBL22712046 0.78 DGAT1 (0.46) AAK1ROCK2LPLLIPGDGAT1
SCHEMBL29714387 0.78 AAK1 (0.35) AAK1LPLLIPGPDGFRBKDR
SCHEMBL22778072 0.78 AAK1 (0.35) AAK1LPLLIPGPDGFRBKDR
SCHEMBL16175196 0.78 AAK1 (0.46) AAK1ALPLLPLLIPGDGAT1
SCHEMBL22026484 0.76 AAK1 (0.48) AAK1ALPLLPLLIPGDGAT1
SCHEMBL20746364 0.76 AAK1 (0.48) AAK1ALPLLPLLIPGDGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250376475-A1 ION CHANNEL MODULATORS PRAXIS PREC MEDICINES INC (US) 2025-12-11 — — US disclosed
US-20250163068-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2025-05-22 — — US disclosed
EP-4487916-A2 ION CHANNEL MODULATORS Praxis Precision Medicines, Inc. (US) 2025-01-08 — — EP disclosed
EP-4397308-A2 COMPOUNDS AND THEIR METHODS OFUSE Praxis Precision Medicines, Inc. (US) 2024-07-10 — — EP disclosed
US-20240132501-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. (US) 2024-04-25 — — US disclosed
EP-3548033-B1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PREC MEDICINES INC (US) 2024-04-10 — — EP disclosed
CN-117756800-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2024-03-26 — — CN disclosed
US-11918571-B2 Compounds and their methods of use PRAXIS PRECISION MEDICINES, INC. (US) 2024-03-05 — — US disclosed
US-11866439-B2 Ion channel modulators PRAXIS PRECISION MEDICINES, INC. (US) 2024-01-09 — — US disclosed
US-20230322790-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2023-10-12 — — US disclosed
US-11014931-B2 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator PRAXIS PRECISION MEDICINES, INC. (US) 2021-05-25 — — US disclosed
EP-3801535-A1 ION CHANNEL MODULATORS Praxis Precision Medicines, Inc. (US) 2021-04-14 — — EP disclosed
US-20210087197-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-03-25 — — US disclosed
US-20210087197-A1 ION CHANNEL MODULATORS PRAXIS PRECISION MEDICINES, INC. 2021-03-25 — — US disclosed
CN-112423760-A Ion channel modulators 普拉克西斯精密药物股份有限公司 2021-02-26 — — CN disclosed
US-20200179358-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2020-06-11 — — US disclosed
US-20200179358-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. 2020-06-11 — — US disclosed
EP-3548033-A1 COMPOUNDS AND THEIR METHODS OF USE Praxis Precision Medicines, Inc. (US) 2019-10-09 — — EP disclosed
WO-2019035951-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2019-02-21 — — WO disclosed
WO-2018098499-A1 COMPOUNDS AND THEIR METHODS OF USE PRAXIS PRECISION MEDICINES, INC. (US) 2018-05-31 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11918571-B2 Compounds and their methods of use SCN1A, SCN3A, SCN2A CYP1A2 2676/4885AAK1 3505/4885ROCK2 3336/4885
US-20240132501-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885AAK1 2082/4885ROCK2 3704/4885
US-20210087197-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885AAK1 2082/4885ROCK2 3704/4885
US-11866439-B2 Ion channel modulators SCN1A, SCN3A, SCN2A CYP1A2 2873/4885AAK1 2082/4885ROCK2 3704/4885
US-20250163068-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B CYP1A2 1988/4885AAK1 3892/4885ROCK2 2876/4885
US-11014931-B2 3-(ethoxydifluoromethyl)-6-(5-fluoro-6-(2,2,2-trifluoroethoxy)pyridin-3-yl)-[1,2,4]triazolo[4,3-a]pyrazine as an ion channel modulator SCN3A, SCN1A, SCN5A CYP1A2 2631/4885AAK1 1437/4885ROCK2 3952/4885
US-20250376475-A1 ION CHANNEL MODULATORS SCN1A, SCN3A, SCN2A CYP1A2 2873/4885AAK1 2082/4885ROCK2 3704/4885
US-20200179358-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN2A CYP1A2 2676/4885AAK1 3505/4885ROCK2 3336/4885
US-20230322790-A1 COMPOUNDS AND THEIR METHODS OF USE SCN1A, SCN3A, SCN1B CYP1A2 1988/4885AAK1 3892/4885ROCK2 2876/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.