Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 11/20 | 0.49 |
| ▸ | FASN | P49327 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12877336 | 0.95 | HSD11B1 (0.50) | MEN1KMT2AHSD11B1FASNALDH1A1 | |
| SCHEMBL31239745 | 0.90 | HSD11B1 (0.45) | MEN1KMT2AHSD11B1FASNALDH1A1 | |
| SCHEMBL22563174 | 0.83 | FASN (0.43) | MEN1KMT2AHSD11B1FASNALDH1A1 | |
| Bicarbonate SCHEMBL9497728 | 0.80 | CA2 (0.47) | MEN1KMT2AHSD11B1FASNALDH1A1 | |
| SCHEMBL5489277 | 0.79 | — | — | |
| SCHEMBL3401333 | 0.79 | FASN (0.50) | MEN1KMT2AHSD11B1FASNALDH1A1 | |
| SCHEMBL19185241 | 0.76 | SMN1; SMN2 (0.50) | MEN1KMT2AFASNALDH1A1SMN1; SMN2 | |
| SCHEMBL1158843 | 0.76 | HSD11B1 (0.47) | HSD11B1FASNL3MBTL1 | |
| SCHEMBL8392977 | 0.74 | HSD11B1 (0.48) | MEN1KMT2AHSD11B1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8392077 | 0.74 | HSD11B1 (0.48) | MEN1KMT2AHSD11B1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513098-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011075515-A1 | AMINOPYRIMIDINES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-06-23 | — | — | WO | disclosed |