Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 11/20 | 0.50 |
| ▸ | FASN | P49327 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2019178 | 0.95 | MEN1 (0.52) | HSD11B1FASNMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL31239745 | 0.90 | HSD11B1 (0.45) | HSD11B1FASNMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3401333 | 0.83 | FASN (0.50) | HSD11B1FASNMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19185241 | 0.80 | SMN1; SMN2 (0.50) | FASNMEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL1158843 | 0.80 | HSD11B1 (0.47) | HSD11B1FASNL3MBTL1 | |
| SCHEMBL5489277 | 0.79 | — | — | |
| SCHEMBL22563174 | 0.79 | FASN (0.43) | HSD11B1FASNMEN1KMT2ASMN1; SMN2 | |
| Bicarbonate SCHEMBL9497728 | 0.76 | CA2 (0.47) | HSD11B1FASNMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL8393764 | 0.74 | HSD11B1 (0.53) | HSD11B1MEN1KMT2ASMN1; SMN2L3MBTL1 | |
| SCHEMBL13321320 | 0.74 | HSD11B1 (0.42) | HSD11B1MEN1KMT2ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8394789-B2 | (Dihydro)pyrrolo[2,1-α]isoquinolines | MSD OSS B.V. (NL) | 2013-03-12 | — | — | US | disclosed |
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | N.V. ORGANON (NL) | 2011-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110039832-A1 | DIHYDRO)PYRROLO[2,1-A]ISOQUINOLINES | PKD2, PKD1, CATSPER1 | HSD11B1 697/4885FASN 4020/4885MEN1 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.