Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 5/20 | 0.33 |
| ▸ | WNT1 | P04628 | 3/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20193216 | 0.92 | CHUK (0.40) | CHUKAXLTYRO3MERTK | |
| SCHEMBL20193228 | 0.91 | MTOR (0.33) | CHUKAXLTYRO3MERTKGPR119 | |
| SCHEMBL16608288 | 0.89 | DGAT1 (0.35) | GSK3BDYRK1AWNT1CHUKAXL | |
| SCHEMBL20193253 | 0.87 | AXL (0.32) | CHUKAXLTYRO3MERTK | |
| SCHEMBL19114444 | 0.87 | CHUK (0.33) | CHUKAXLTYRO3MERTKGPR119 | |
| SCHEMBL20193254 | 0.85 | AXL (0.32) | CHUKAXLTYRO3MERTK | |
| SCHEMBL20193218 | 0.84 | GPR119 (0.37) | CHUKGPR119 | |
| SCHEMBL20193160 | 0.84 | CHUK (0.54) | CHUK | |
| SCHEMBL16608483 | 0.81 | CHUK (0.40) | CHUKAXLTYRO3MERTK | |
| SCHEMBL20193179 | 0.81 | CREBBP (0.32) | GSK3BCHUKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981963-B2 | 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-29 | — | — | US | disclosed |