Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 2/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.32 |
| ▸ | MERTK | Q12866 | 2/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | CCND3 | P30281 | 1/20 | 0.31 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19114444 | 0.96 | CHUK (0.33) | MTORGPR119CHUKAXLTYRO3 | |
| SCHEMBL20193156 | 0.91 | GSK3B (0.33) | GPR119CHUKAXLTYRO3MERTK | |
| SCHEMBL16608578 | 0.90 | DGAT1 (0.35) | MTORFGFR1FGFR2FGFR3CHUK | |
| SCHEMBL20193216 | 0.89 | CHUK (0.40) | CHUKAXLTYRO3MERTK | |
| SCHEMBL19114373 | 0.85 | CHUK (0.51) | CHUK | |
| SCHEMBL20193253 | 0.85 | AXL (0.32) | MTORCHUKAXLTYRO3MERTK | |
| SCHEMBL20193244 | 0.84 | PIK3CD (0.33) | MTORCHUKPIK3CDPIK3CBPIK3CG | |
| SCHEMBL20193254 | 0.84 | AXL (0.32) | CHUKAXLTYRO3MERTK | |
| SCHEMBL20193218 | 0.83 | GPR119 (0.37) | MTORGPR119CHUKJAK1 | |
| SCHEMBL16608288 | 0.80 | DGAT1 (0.35) | CHUKAXLTYRO3MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981963-B2 | 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-29 | — | — | US | disclosed |