Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | PKM | P14618 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11666941 | 0.84 | LMNA (0.67) | LMNAPKMALDH1A1HCAR3KMT2A | |
| SCHEMBL10485197 | 0.84 | PKM (0.65) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL2245974 | 0.82 | ALDH1A1 (0.61) | LMNAPKMALDH1A1HCAR3KMT2A | |
| SCHEMBL10485251 | 0.81 | ALDH1A1 (0.67) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL3369999 | 0.81 | KMT2A (0.69) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL5951699 | 0.81 | KMT2A (0.71) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL6286684 | 0.81 | PKM (0.59) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL4689794 | 0.81 | ALDH1A1 (0.59) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL6982251 | 0.80 | KMT2A (0.58) | LMNAPKMALDH1A1KMT2AMEN1 | |
| SCHEMBL31327395 | 0.80 | ALDH1A1 (0.56) | LMNAPKMALDH1A1HCAR3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |
| WO-2011079087-A1 | ENAC BLOCKERS | GLAXO GROUP LIMITED (GB) | 2011-06-30 | — | — | WO | disclosed |