Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.39 |
| ▸ | PRKCG | P05129 | 1/20 | 0.37 |
| ▸ | PRKCB | P05771 | 1/20 | 0.37 |
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | PRKCH | P24723 | 1/20 | 0.37 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.37 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16608659 | 0.91 | PRKCG (0.37) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL19114604 | 0.91 | PRKCG (0.37) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL19629574 | 0.88 | GPR119 (0.38) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL19114165 | 0.88 | GPR119 (0.42) | GPR119PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL20193157 | 0.85 | — | — | |
| SCHEMBL19629423 | 0.80 | IL1B (0.33) | GPR119SRCSCN9A | |
| SCHEMBL20193213 | 0.80 | GPR119 (0.36) | GPR119SRC | |
| SCHEMBL19629472 | 0.80 | SCN9A (0.36) | GPR119KDM1ASRCSCN9A | |
| SCHEMBL20193218 | 0.79 | GPR119 (0.37) | GPR119KDM1A | |
| SCHEMBL19626265 | 0.78 | PRKCG (0.37) | GPR119PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9981963-B2 | 3-(1H-pyrazol-4-yl)-1H-pyrrolo[2,3-c]pyridine derivatives as NIK inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2018-05-29 | — | — | US | disclosed |