Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 10/20 | 0.42 |
| ▸ | S1PR4 | O95977 | 3/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.42 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194125 | 0.84 | GAA (0.41) | KDM4EHPGD | |
| SCHEMBL20194121 | 0.76 | F2 (0.46) | KDM4ELMNASMN1; SMN2S1PR3S1PR4 | |
| SCHEMBL20194127 | 0.75 | S1PR3 (0.38) | SMN1; SMN2S1PR3S1PR4S1PR1S1PR5 | |
| SCHEMBL5050812 | 0.72 | NPC1 (0.56) | KDM4ELMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL21998506 | 0.71 | ALDH1A1 (0.51) | LMNASMN1; SMN2S1PR3S1PR4S1PR1 | |
| SCHEMBL7105778 | 0.70 | PRKCI (0.56) | KDM4ELMNASMN1; SMN2NPC1CASP3 | |
| SCHEMBL7913711 | 0.70 | KDM4E (0.50) | KDM4ELMNASMN1; SMN2NPC1CASP3 | |
| SCHEMBL20194149 | 0.70 | CA12 (0.34) | LMNAS1PR3S1PR4S1PR2 | |
| SCHEMBL312298 | 0.69 | SRD5A2 (0.53) | KDM4ELMNASMN1; SMN2NPC1RAB9A | |
| SCHEMBL21099277 | 0.69 | KDM4E (0.50) | KDM4ELMNASMN1; SMN2NPC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |