Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.46 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302175 | 0.80 | F2 (0.56) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL21998506 | 0.80 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL20194124 | 0.78 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 | |
| SCHEMBL20194149 | 0.78 | CA12 (0.34) | ALDH1A1LMNAS1PR3S1PR2S1PR4 | |
| SCHEMBL20194126 | 0.77 | SLC6A3 (0.36) | ALDH1A1S1PR3RAB9AS1PR1 | |
| SCHEMBL20194127 | 0.77 | S1PR3 (0.38) | ALDH1A1MAPTSMN1; SMN2S1PR3S1PR2 | |
| SCHEMBL20194125 | 0.77 | GAA (0.41) | ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL20194159 | 0.76 | KDM4E (0.52) | KDM4ENPC1LMNASMN1; SMN2S1PR3 | |
| SCHEMBL22649481 | 0.76 | S1PR3 (0.40) | ALDH1A1MAPTSMN1; SMN2HSD17B10S1PR3 | |
| SCHEMBL10401280 | 0.75 | F2 (0.46) | F2PLGPRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3054955-B1 | PYRROLOTRIAZINE KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-30 | — | — | EP | disclosed |