Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 17/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | NCOR1 | O75376 | 2/20 | 0.39 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194284 | 0.75 | HDAC1 (0.60) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL20194290 | 0.74 | HDAC1 (0.48) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL20194283 | 0.73 | HDAC1 (0.52) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL20194294 | 0.70 | HDAC1 (0.48) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL20194287 | 0.64 | HDAC1 (0.54) | HDAC1HDAC2HDAC3HDAC8NCOR2 | |
| SCHEMBL4714558 | 0.64 | HDAC1 (0.63) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL8401704 | 0.63 | HDAC1 (0.89) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL20194285 | 0.63 | PTGER4 (0.46) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL20194279 | 0.63 | NPC1 (0.47) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL8238564 | 0.62 | HDAC1 (0.59) | HDAC1HDAC2HDAC3HDAC4HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970139-B1 | HDAC INHIBITORS | BIOMARIN PHARM INC (US) | 2018-05-30 | — | — | EP | disclosed |