Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | NR2F2 | P24468 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.50 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.50 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.50 |
| ▸ | FKBP4 | Q02790 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.50 |
| ▸ | FKBP14 | Q9NWM8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6871170 | 0.86 | SMN1; SMN2 (0.41) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL268203 | 0.78 | TSHR (0.37) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL21587611 | 0.78 | TSHR (0.37) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL522950 | 0.78 | TSHR (0.37) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL2691391 | 0.78 | — | — | |
| SCHEMBL102073 | 0.75 | IRAK4 (0.35) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL7082613 | 0.74 | MAPT (0.60) | SMN1; SMN2NR2F2ALDH1A1LMNANPC1 | |
| SCHEMBL886958 | 0.74 | GLA (0.47) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL22060611 | 0.74 | SMN1; SMN2 (0.35) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA | |
| SCHEMBL29332040 | 0.74 | SMN1; SMN2 (0.38) | CRBNSMN1; SMN2NR2F2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 154 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119979516-A | Dihydropyrimidinase mutant and application thereof in production of (R) -3- (carbamoylmethyl) -5-methylhexanoic acid | 上海奥萝拉医药科技有限公司 | 2025-05-13 | — | — | CN | claimed |
| CN-119955872-A | Synthetic protein of R- (-) -3- (carbamoylmethyl) -5-methylhexanoic acid, mutant and application thereof | 中国科学院微生物研究所 | 2025-05-09 | — | — | CN | claimed |
| CN-119570777-A | Preparation and application of immobilized hydantoin enzyme | 宁波酶赛生物工程有限公司 | 2025-03-07 | — | — | CN | claimed |
| US-20250043323-A1 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES | Enzymaster (Ningbo) Bio-Engineering Co., Ltd (CN) | 2025-02-06 | — | — | US | claimed |
| CN-114164198-B | (R) - (-) -3- (carbamoylmethyl) -5-methylhexanoic acid synthetic protein, mutant and application thereof | 中国科学院微生物研究所 | 2025-01-07 | — | — | CN | claimed |
| EP-4433602-A1 | BIOCATALYSTS AND METHODS FOR THE SYNTHESIS OF PREGABALIN INTERMEDIATES | Enzymaster (Ningbo) Bio-Engineering Co., Ltd. (CN) | 2024-09-25 | — | — | EP | claimed |
| CN-113755539-B | Dihydropyrimidine amino hydrolase and application thereof | 杭州酶因生物技术有限公司 | 2024-05-28 | — | — | CN | claimed |
| CN-118064412-A | Amidase, preparation method and application thereof | 弈柯莱生物科技(集团)股份有限公司 | 2024-05-24 | — | — | CN | claimed |
| CN-114686465-B | Synthesis method of hydrolase and (R) - (-) -3- (carbamoylmethyl) -5-methylhexanoic acid | 宁波酶赛生物工程有限公司 | 2024-03-22 | — | — | CN | claimed |
| CN-117448309-A | Preparation method of immobilized sea weed enzyme and application of immobilized sea weed enzyme in pregabalin intermediate | 迪嘉药业集团股份有限公司 | 2024-01-26 | — | — | CN | claimed |
| CN-112521299-A | Preparation method of pregabalin intermediate | 内蒙古永太化学有限公司 | 2021-03-19 | — | — | CN | claimed |
| CN-112368262-A | Method for preparing pregabalin intermediate (R) -3- (carbamoylmethyl) -5-methylhexanoic acid | 浙江华海药业股份有限公司 | 2021-02-12 | — | — | CN | claimed |
| WO-2019232706-A1 | METHOD FOR PREPARING PREGABALIN INTERMEDIATE (R)-3-(CARBAMOYLMETHYL)-5-METHYLHEXANOIC ACID | 浙江华海药业股份有限公司 (CN) | 2019-12-12 | — | — | WO | claimed |
| CN-105481712-A | Racemization recycling method of Pregabalin intermediate mother liquor from resolution | CHANGZHOU SUNLIGHT PHARM CO LTD | 2016-04-13 | — | — | CN | claimed |
| CN-105001147-A | Preparation method of Pregabalin intermediate impurity | ZHEJIANG HUAHAI PHARM CO LTD | 2015-10-28 | — | — | CN | claimed |
| CN-104496832-A | Synthetic method of pregabalin | ZHEJIANG MENOVO PHARMACEUTICALS CO LTD | 2015-04-08 | — | — | CN | claimed |
| CN-104030936-A | Method for preparing 3-carbamoylmethyl-5-methylhexanoic acid | SHANGHAI ACEBRIGHT PHARMACEUTICAL CO LTD | 2014-09-10 | — | — | CN | claimed |
| WO-2011077463-A1 | PROCESS FOR PREPARING PREGABALIN AND ITS INTERMEDIATE | MSN LABORATORIES LIMITED (IN) | 2011-06-30 | — | — | WO | claimed |
| CN-100410242-C | Pregabalin intermediate and process for preparing same | JIANGSU NHWA PHARMACEUTICAL GR (CN) | 2008-08-13 | — | — | CN | claimed |
| CN-1884263-A | Pregabalin intermediate and process for preparing same | JIANGSU NHWA PHARMACEUTICAL GR (CN) | 2006-12-27 | — | — | CN | claimed |