Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21587611 | 1.00 | TSHR (0.37) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL522950 | 1.00 | TSHR (0.37) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3117336 | 0.85 | TSHR (0.33) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29332923 | 0.85 | SMN1; SMN2 (0.37) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6923351 | 0.84 | TSHR (0.35) | TSHRPDE4APDE4BPDE4CPDE4D | |
| Valine SCHEMBL576798 | 0.83 | SLC7A5 (0.43) | IRAK4 | |
| SCHEMBL3123099 | 0.82 | PDE4A (0.39) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3123114 | 0.82 | PDE4A (0.39) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27488017 | 0.82 | PDE4A (0.39) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3114190 | 0.81 | TSHR (0.33) | TSHRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111929370-B | Method for detecting related substances in pregabalin oral solution | 中国人民解放军军事科学院军事医学研究院 | 2022-07-01 | — | — | CN | claimed |
| CN-111929370-A | Method for detecting related substances in pregabalin oral solution | 中国人民解放军军事科学院军事医学研究院 | 2020-11-13 | — | — | CN | claimed |
| CN-110963934-A | Method for synthesizing and refining (S) -pregabalin | 浙江竹子制药有限公司 | 2020-04-07 | — | — | CN | claimed |
| US-20240423937-A1 | METHODS OF TREATING PAIN AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2024-12-26 | — | — | US | disclosed |
| US-20240156765-A1 | METHODS OF NEUROPROTECTION AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2024-05-16 | — | — | US | disclosed |
| US-20240041808-A1 | METHODS OF NEUROPROTECTION AND USES THEREOF | UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION | 2024-02-08 | — | — | US | disclosed |
| WO-2023028490-A1 | METHODS OF TREATING PAIN AND USES THEREOF | OCULOTHERAPY, LLC (US) | 2023-03-02 | — | — | WO | disclosed |
| CN-111929370-B | Method for detecting related substances in pregabalin oral solution | 中国人民解放军军事科学院军事医学研究院 | 2022-07-01 | — | — | CN | disclosed |
| EP-3819290-A1 | METHOD FOR PREPARING PREGABALIN | Zhejiang Huahai Pharmaceutical Co., Ltd (CN) | 2021-05-12 | — | — | EP | disclosed |
| US-20210114972-A1 | METHOD FOR PREPARING PREGABALIN | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD. (CN) | 2021-04-22 | — | — | US | disclosed |
| CN-109232311-B | Green and efficient synthesis method of pregabalin | 浙江新和成股份有限公司 | 2021-02-19 | — | — | CN | disclosed |
| WO-2009010554-A1 | PROCESS FOR THE ENANTIOSELECTIVE PREPARATION OF PREGABALIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-01-22 | — | — | WO | disclosed |
| CN-101300224-A | Process for making (s)-pregabalin | TEVA PHARMA (IL) | 2008-11-05 | — | — | CN | disclosed |
| WO-2008127646-A2 | TRANSAMINASE-BASED PROCESSES FOR PREPARATION OF PREGABALIN | DSM IP ASSETS B.V. (NL) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008127646-A2 | TRANSAMINASE-BASED PROCESSES FOR PREPARATION OF PREGABALIN | DSM IP ASSETS B.V. (NL) | 2008-10-23 | — | — | WO | disclosed |
| EP-1768950-A2 | PROCESS FOR MAKING (S)-PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-04-04 | — | — | EP | disclosed |
| US-20070066846-A1 | Process for making (S)-Pregabalin | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-22 | — | — | US | disclosed |
| US-20070066846-A1 | Process for making (S)-Pregabalin | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-03-22 | — | — | US | disclosed |
| WO-2006121557-A1 | PREGABALIN FREE OF LACTAM AND A PROCESS FOR PREPARATION THEREOF | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006110783-A2 | PROCESS FOR MAKING (S)-PREGABALIN | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240041808-A1 | METHODS OF NEUROPROTECTION AND USES THEREOF | NLN, BDNF, GAP43 | TSHR 3865/4885PDE4A 789/4885PDE4B 829/4885 |
| US-20210114972-A1 | METHOD FOR PREPARING PREGABALIN | GABRD, GABRB2, GABRP | TSHR 3673/4885PDE4A 1953/4885PDE4B 1560/4885 |
| US-20240423937-A1 | METHODS OF TREATING PAIN AND USES THEREOF | ACHE, PDE6G, PTGES3 | TSHR 3771/4885PDE4A 48/4885PDE4B 130/4885 |
| US-20240156765-A1 | METHODS OF NEUROPROTECTION AND USES THEREOF | NLN, BDNF, GAP43 | TSHR 3865/4885PDE4A 789/4885PDE4B 829/4885 |
| US-20070066846-A1 | Process for making (S)-Pregabalin | GABRE, GABRA6, GABRA5 | TSHR 4132/4885PDE4A 2719/4885PDE4B 2809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.