Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | NR2F2 | P24468 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | EIF4A1 | P60842 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21587611 | 1.00 | TSHR (0.37) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL268203 | 1.00 | TSHR (0.37) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3117336 | 0.85 | TSHR (0.33) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29332923 | 0.85 | SMN1; SMN2 (0.37) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6923351 | 0.84 | TSHR (0.35) | TSHRPDE4APDE4BPDE4CPDE4D | |
| Valine SCHEMBL576798 | 0.83 | SLC7A5 (0.43) | IRAK4 | |
| SCHEMBL3123099 | 0.82 | PDE4A (0.39) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3123114 | 0.82 | PDE4A (0.39) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL27488017 | 0.82 | PDE4A (0.39) | TSHRPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3114190 | 0.81 | TSHR (0.33) | TSHRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 210 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143179-B1 | AZETIDIN-3-YLMETHANOL DERIVATIVES AS CCR6 RECEPTOR MODULATORS FOR THE TREATMENT OF CANCER | IDORSIA PHARMACEUTICALS LTD (CH) | 2025-10-22 | — | — | EP | claimed |
| CN-119569633-A | Pregabalin lactam methylene dimer and preparation method thereof | 浙江华海药业股份有限公司 | 2025-03-07 | — | — | CN | claimed |
| US-12018018-B2 | Pregabalin lactam methylene dimer and preparation method therefor | ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD (CN) | 2024-06-25 | — | — | US | claimed |
| CN-117665163-A | Method for detecting related substances in pregabalin | 上海佰利源医药科技有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-109851543-B | Method for preparing S-pregabalin lactam | 浙江华海药业股份有限公司 | 2023-07-07 | — | — | CN | claimed |
| CN-115475162-B | Application of 4-isobutyl-2-pyrrolidone in preparing analgesic drug and analgesic drug | 浙江震元制药有限公司 | 2023-06-02 | — | — | CN | claimed |
| US-20230106270-A1 | Acetaminophen-Pregabalin Combinations And Methods Of Treating Pain | NEVAKAR INJECTABLES INC. (US) | 2023-04-06 | — | — | US | claimed |
| US-11547686-B2 | Acetaminophen pregabalin combinations and methods of treating pain | NEVAKAR INJECTABLES INC. (US) | 2023-01-10 | — | — | US | claimed |
| CN-115475162-A | Application of 4-isobutyl-2-pyrrolidone in preparation of analgesic and analgesic drug | 浙江震元制药有限公司 | 2022-12-16 | — | — | CN | claimed |
| WO-2022256545-A1 | INJECTABLE PREGABALIN FORMULATIONS | NEVAKAR INJECTABLES INC. (US) | 2022-12-08 | — | — | WO | claimed |
| CN-111432882-A | Acetaminophen-pregabalin combinations and methods of treating pain | 内瓦卡公司 | 2020-07-17 | — | — | CN | claimed |
| CN-110963934-A | Method for synthesizing and refining (S) -pregabalin | 浙江竹子制药有限公司 | 2020-04-07 | — | — | CN | claimed |
| CN-110903228-A | Preparation method of 4-isobutyl pyrrolidone by solvent-free method | 南通常佑药业科技有限公司 | 2020-03-24 | — | — | CN | claimed |
| WO-2019070641-A1 | ACETAMINOPHEN-PREGABALIN COMBINATIONS AND METHODS OF TREATING PAIN | NEVAKAR INC. (US) | 2019-04-11 | — | — | WO | claimed |
| CN-102952057-B | A kind of preparation method of 4-isobutyl-pyrrolidin-2-one | ZHEJIANG APELOA HOME PHARMACEUTICAL CO.,LTD. (CN) | 2015-09-09 | — | — | CN | claimed |
| CN-104395286-A | Preparation method of lactam compound | GUANGDONG HEC PHARMACEUTICAL | 2015-03-04 | — | — | CN | claimed |
| WO-2014005494-A1 | METHOD OF PREPARING LACTAM COMPOUND | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-01-09 | — | — | WO | claimed |
| CN-102952057-A | Preparation method of 4-isobutyl pyrrolidine-2-ketone | ZHEJIANG APELOA JIAYUAN PHARMACEUTICAL CO LTD | 2013-03-06 | — | — | CN | claimed |
| EP-1377318-A2 | PREGABALIN LACTOSE CONJUGATES | Warner-Lambert Company LLC (US) | 2004-01-07 | — | — | EP | claimed |
| WO-2002078747-A2 | PREGABALIN LACTOSE CONJUGATES | WARNER-LAMBERT COMPANY LLC (US) | 2002-10-10 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12018018-B2 | Pregabalin lactam methylene dimer and preparation method therefor | GABRD, GABRG2, GABRG1 | TSHR 4509/4885PDE4A 4018/4885PDE4B 3329/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.