Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | IL2RA | P01589 | 1/20 | 0.38 |
| ▸ | ALB | P02768 | 1/20 | 0.38 |
| ▸ | IL2 | P60568 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | YAP1 | P46937 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18912329 | 0.89 | GAA (0.54) | GAATSHRCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL19647312 | 0.89 | GAA (0.54) | GAATSHRCYP2C9CYP2C19ALDH1A1 | |
| SCHEMBL22561427 | 0.87 | KLKB1 (0.44) | TSHRKMT2AMMP1 | |
| SCHEMBL22810961 | 0.82 | POLB (0.49) | GAAALDH1A1HSD17B10POLBKMT2A | |
| SCHEMBL21699252 | 0.82 | POLB (0.49) | GAAALDH1A1HSD17B10POLBKMT2A | |
| SCHEMBL15313443 | 0.82 | POLB (0.49) | GAAALDH1A1HSD17B10POLBKMT2A | |
| SCHEMBL2734908 | 0.82 | POLB (0.49) | GAAALDH1A1HSD17B10POLBKMT2A | |
| SCHEMBL9892967 | 0.82 | POLB (0.49) | GAAALDH1A1HSD17B10POLBKMT2A | |
| SCHEMBL21781767 | 0.81 | MMP13 (0.37) | — | |
| SCHEMBL23209734 | 0.79 | ATM (0.54) | GAACYP2C9CYP2C19ALDH1A1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3327027-A1 | CYTOTOXIC PEPTIDES AND ANTIBODY DRUG CONJUGATES THEREOF | Pfizer Inc (US) | 2018-05-30 | — | — | EP | disclosed |