Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.35 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.35 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.35 |
| ▸ | EIF4E | P06730 | 15/20 | 0.35 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20197223 | 0.85 | SREBF2 (0.42) | KDM4E | |
| SCHEMBL16535445 | 0.83 | KDM1A (0.40) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197238 | 0.79 | CYP19A1 (0.44) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197481 | 0.77 | EIF4E (0.37) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197479 | 0.77 | EIF4E (0.39) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197337 | 0.76 | CYP1A2 (0.40) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197235 | 0.76 | SREBF2 (0.42) | KDM4E | |
| SCHEMBL20197301 | 0.76 | KDM4E (0.34) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197443 | 0.73 | C1S (0.39) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A | |
| SCHEMBL20197368 | 0.73 | MAPK14 (0.35) | KDM4ESMN1; SMN2NPC1CRHBPRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3038622-B1 | HETEROCYCLIC COMPOUNDS AND METHODS OF USE | MEDIVATION TECH LLC (US) | 2018-05-30 | — | — | EP | disclosed |