SCHEMBL20197289

SCHEMBL20197289

CCCc1ccnc(I)c1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOS2 P35228 2/20 0.39
NOS3 P29474 1/20 0.39
NOS1 P29475 1/20 0.39
CNR1 P21554 1/20 0.39
CNR2 P34972 1/20 0.39
LMNA P02545 2/20 0.37
KDM4E B2RXH2 1/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
TLR8 Q9NR97 1/20 0.34
HDAC8 Q9BY41 1/20 0.33
MEN1 O00255 1/20 0.33
ALDH1A1 P00352 1/20 0.33
HTT P42858 1/20 0.33
KMT2A Q03164 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
NISCH Q9Y2I1 1/20 0.33
HTR1D P28221 1/20 0.33
LOX P28300 1/20 0.32
LOXL2 Q9Y4K0 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2463503 0.86 TDP1 (0.44) LMNAKDM4ECYP3A4ALDH1A1L3MBTL1
SCHEMBL13185473 0.83
SCHEMBL487201 0.78 KDM4E (0.56) NOS2NOS3NOS1CNR1CNR2
SCHEMBL12826953 0.78 CCR1 (0.44) NOS2NOS3NOS1CNR1CNR2
SCHEMBL26272350 0.78 ESR1 (0.38) NOS2NOS3NOS1HDAC8LOX
SCHEMBL487318 0.77 UHRF1 (0.48) NOS2NOS3NOS1CNR1CNR2
SCHEMBL2619306 0.77 CYP1A2 (0.47) NOS2NOS3NOS1CNR1CNR2
SCHEMBL27918778 0.76 LNPEP (0.37) LMNAKDM4ECYP3A4TLR8ALDH1A1
SCHEMBL4438687 0.75 RECQL (0.59) NOS2NOS3NOS1CNR1CNR2
SCHEMBL294326 0.75 NOS2 (0.39) NOS2NOS3NOS1CNR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3038622-B1 HETEROCYCLIC COMPOUNDS AND METHODS OF USE MEDIVATION TECH LLC (US) 2018-05-30 EP disclosed