SCHEMBL20197379

SCHEMBL20197379

C=Cc1cc(C(C)(C)F)ccc1C

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.31
PDE2A O00408 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14536243 0.86 PDE2A (0.38) PDE2A
SCHEMBL183161 0.84 MAPT (0.42) ESR1
SCHEMBL32671491 0.84 MAPT (0.42) ESR1
SCHEMBL23592890 0.77 ALDH1A1 (0.40) ESR1PDE2A
SCHEMBL12329720 0.73 PDE2A (0.37) PDE2A
SCHEMBL30233883 0.72 CYP1A1 (0.43) PDE2A
SCHEMBL25026056 0.72 CYP1A1 (0.43) PDE2A
SCHEMBL28259163 0.72 ALOX5 (0.35)
SCHEMBL12958097 0.71 MEN1 (0.37)
SCHEMBL9719103 0.70 TSHR (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3327019-A1 HETEROCYCLIC COMPOUND Takeda Pharmaceutical Company Limited (JP) 2018-05-30 EP disclosed