Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | CASP2 | P42575 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22834424 | 0.78 | BIRC2 (0.41) | MMP1MMP2MMP3 | |
| SCHEMBL24920432 | 0.78 | MAPT (0.33) | MCL1 | |
| SCHEMBL28744602 | 0.74 | NAAA (0.49) | ACHEEPHX1CASP2 | |
| SCHEMBL13475438 | 0.74 | MCL1 (0.45) | MCL1BCHEACHEMMP1MMP2 | |
| SCHEMBL26151157 | 0.74 | MCL1 (0.45) | MCL1BCHEACHEMMP1MMP2 | |
| SCHEMBL1577892 | 0.73 | SMN1; SMN2 (0.53) | MCL1HPGDMMP1MMP2MMP3 | |
| SCHEMBL9620366 | 0.73 | TSHR (0.42) | MMP1MMP2MEN1KMT2ATSHR | |
| SCHEMBL5907647 | 0.71 | ALDH1A1 (0.48) | MCL1BCHEACHEMMP1MMP2 | |
| SCHEMBL5986606 | 0.71 | MCL1 (0.47) | MCL1MMP1MMP2MMP3MMP9 | |
| SCHEMBL13475439 | 0.71 | MCL1 (0.42) | MCL1BCHEACHEMMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2917195-B9 | SPLICEOSTATIN ANALOGS | PFIZER (US) | 2018-05-30 | — | — | EP | disclosed |