Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALPI | P09923 | 1/20 | 0.36 |
| ▸ | ALPG | P10696 | 1/20 | 0.36 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.30 |
| ▸ | KLK1 | P06870 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12017393 | 0.82 | LMNA (0.39) | LMNAHTTSMN1; SMN2GAAKMT2A | |
| SCHEMBL18963615 | 0.79 | — | — | |
| SCHEMBL6936934 | 0.79 | LMNA (0.40) | LMNAHTTSMN1; SMN2GAAKMT2A | |
| SCHEMBL23989363 | 0.77 | LMNA (0.36) | LMNAHTTSMN1; SMN2GAAKMT2A | |
| SCHEMBL17793164 | 0.77 | LMNA (0.36) | LMNAHTTSMN1; SMN2GAAKMT2A | |
| SCHEMBL292775 | 0.75 | — | — | |
| SCHEMBL17672754 | 0.75 | — | — | |
| SCHEMBL23174811 | 0.75 | LMNA (0.38) | LMNAHTTSMN1; SMN2GAAKMT2A | |
| SCHEMBL20420208 | 0.74 | TBXAS1 (0.46) | LMNASMN1; SMN2GAAALDH1A1 | |
| SCHEMBL16769196 | 0.74 | DUT (0.37) | LMNAHTTSMN1; SMN2GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-B1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LTD (GB) | 2018-05-30 | — | — | EP | disclosed |