SCHEMBL20198518

SCHEMBL20198518

CCCCCCNc1ccc(C(F)(F)F)cc1N

nearest known ligand 0.52

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.47
L3MBTL1 Q9Y468 3/20 0.47
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 2/20 0.47
GAA P10253 2/20 0.47
MEN1 O00255 1/20 0.47
GFER P55789 1/20 0.47
KMT2A Q03164 1/20 0.47
PRSS1 P07477 8/20 0.46
POLB P06746 1/20 0.43
PLK1 P53350 1/20 0.41
HSD17B10 Q99714 1/20 0.40
PTGER4 P35408 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
CFTR P13569 1/20 0.39
MCHR1 Q99705 1/20 0.39
LMNA P02545 1/20 0.39
ATM Q13315 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7191685 0.94 L3MBTL1 (0.49) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL356336 0.88 L3MBTL1 (0.51) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL11506360 0.82 ALDH1A1 (0.49) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL4800829 0.81 MAPT (0.46) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL356011 0.81 ALDH1A1 (0.54) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL5023620 0.78 ALDH1A1 (0.51) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL21016436 0.78 HDAC6 (0.61) MAPTKDM4EALDH1A1GAAPRSS1
SCHEMBL14015050 0.78 L3MBTL1 (0.51) MAPTL3MBTL1ALDH1A1GAAMEN1
SCHEMBL8342305 0.78 PTGER4 (0.56) MAPTL3MBTL1KDM4EALDH1A1GAA
SCHEMBL27684987 0.78 ALDH1A1 (0.48) MAPTL3MBTL1KDM4EALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1712242-B1 METHOD OF REGULATING PHOSPHORYLATION OF SR PROTEIN AND ANTIVIRAL AGENTS COMPRISING SR PROTEIN ACTIVITY REGULATOR AS THE ACTIVE INGREDIENT HAGIWARA MASATOSHI (JP) 2018-05-30 EP disclosed