Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20198925 | 0.83 | POLB (0.31) | POLB | |
| SCHEMBL20198948 | 0.81 | HPGD (0.33) | POLB | |
| SCHEMBL25495724 | 0.80 | PGR (0.38) | KDM4ENPSR1POLBTHRBMEN1 | |
| SCHEMBL20174739 | 0.79 | NTRK1 (0.40) | KDM4ETP53THRBMEN1MAPT | |
| SCHEMBL17367234 | 0.74 | NTRK1 (0.39) | KDM4EPOLBTP53MEN1MAPT | |
| SCHEMBL20199161 | 0.74 | KDM4E (0.30) | KDM4EMEN1MAPTMAPK1KMT2A | |
| SCHEMBL27389039 | 0.72 | ALOX5 (0.34) | KDM4ENPSR1MEN1KMT2A | |
| SCHEMBL18506266 | 0.72 | NTRK1 (0.37) | KDM4ETP53MEN1MAPTKMT2A | |
| SCHEMBL20198931 | 0.71 | PTGER4 (0.31) | POLB | |
| SCHEMBL19367132 | 0.70 | KMT2A (0.36) | KDM4ENPSR1POLBMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10781366-B2 | Spiro compound and organic light-emitting device comprising same | LG CHEM, LTD. (KR) | 2020-09-22 | — | — | US | disclosed |
| US-20180148639-A1 | SPIRO COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME | LG CHEM, LTD. (KR) | 2018-05-31 | — | — | US | disclosed |
| US-20180148639-A1 | SPIRO COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME | LG CHEM, LTD. (KR) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10781366-B2 | Spiro compound and organic light-emitting device comprising same | CRY1, NR2E3, ERG | KDM4E 3633/4885NPSR1 3257/4885POLB 4154/4885 |
| US-20180148639-A1 | SPIRO COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME | CRY1, NR2E3, ERG | KDM4E 3633/4885NPSR1 3257/4885POLB 4154/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.