Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MMP13 | P45452 | 1/20 | 0.32 |
| ▸ | MMP14 | P50281 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 3/20 | 0.31 |
| ▸ | JAK3 | P52333 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20200794 | 0.84 | ADAMTS4 (0.32) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL12463409 | 0.77 | JAK2 (0.33) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL18428183 | 0.77 | JAK2 (0.33) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL2625465 | 0.71 | PTGS1 (0.36) | JAK2JAK3 | |
| SCHEMBL5883435 | 0.71 | ADAMTS4 (0.36) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL21859524 | 0.71 | JAK2 (0.37) | JAK2JAK3 | |
| SCHEMBL20190946 | 0.69 | APLNR (0.41) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL20200600 | 0.69 | APLNR (0.41) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL20188961 | 0.69 | APLNR (0.41) | ADAMTS4CYP3A4MMP13MMP14KCNH2 | |
| SCHEMBL19232123 | 0.68 | GPR84 (0.37) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3541792-B1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC (US) | 2020-12-23 | — | — | EP | disclosed |
| WO-2018097944-A1 | TRIAZOLE FURAN COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR | AMGEN INC. (US) | 2018-05-31 | — | — | WO | disclosed |