Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 3/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 3/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | GPR3 | P46089 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13877240 | 0.74 | SLC6A4 (0.46) | SLC6A4CYP1A2CYP2D6HTR5AHTR2A | |
| SCHEMBL20186695 | 0.69 | ABCB1 (0.38) | SLC6A4CYP1A2CYP2D6ALOX15KDM4E | |
| SCHEMBL18201257 | 0.68 | ABCB1 (0.35) | KDM4EABCB1ABCG2 | |
| SCHEMBL14627593 | 0.67 | SLC6A4 (0.48) | SLC6A4CYP1A2CYP2D6HTR5AHTR2A | |
| SCHEMBL10851703 | 0.66 | ABCB1 (0.41) | SLC6A4CYP1A2CYP2D6HTR5AKDM4E | |
| SCHEMBL13877241 | 0.66 | SLC6A4 (0.47) | SLC6A4CYP1A2CYP2D6HTR5AHTR2A | |
| SCHEMBL10689191 | 0.65 | SLC6A4 (0.46) | SLC6A4CYP1A2CYP2D6HTR5AHTR2A | |
| SCHEMBL10804503 | 0.65 | ABCB1 (0.40) | SLC6A4HTR5AKDM4EHSD17B10MAPT | |
| SCHEMBL10854607 | 0.65 | ABCB1 (0.39) | SLC6A4CYP1A2CYP2D6HTR5AKDM4E | |
| SCHEMBL10851137 | 0.65 | HTR5A (0.40) | SLC6A4CYP1A2CYP2D6HTR5AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148442-A1 | Polycyclic Indoline and Indolenine Compounds | IDO1, IDO2, INMT | SLC6A4 927/4885CYP1A2 624/4885CYP2D6 1672/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.