Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.49 |
| ▸ | GAA | P10253 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | POLB | P06746 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2023578 | 0.87 | ABCG2 (0.49) | ABCG2MEN1KMT2APOLBMAPT | |
| SCHEMBL2028780 | 0.86 | MEN1 (0.38) | ABCG2GAAMEN1KMT2APOLB | |
| SCHEMBL2020576 | 0.84 | MEN1 (0.51) | MEN1KMT2AMAPTKDM1A | |
| SCHEMBL2024076 | 0.83 | LIPG (0.41) | ABCG2KDM1A | |
| SCHEMBL2022451 | 0.83 | FEN1 (0.36) | ABCG2MEN1KMT2AMAPTLMNA | |
| SCHEMBL2023148 | 0.82 | MEN1 (0.44) | ABCG2MEN1KMT2A | |
| SCHEMBL2022418 | 0.82 | ABCG2 (0.51) | ABCG2MEN1KMT2AKDM1A | |
| SCHEMBL2023155 | 0.82 | SYK (0.44) | ABCG2KDM1ARAF1BRAF | |
| SCHEMBL2024454 | 0.82 | ABCG2 (0.47) | ABCG2MEN1KMT2AMAPTTP53 | |
| SCHEMBL2023614 | 0.82 | RIPK1 (0.47) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011075747-A1 | THERAPEUTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-06-23 | — | — | WO | disclosed |
| WO-2011075747-A1 | THERAPEUTIC COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-06-23 | — | — | WO | disclosed |