Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 17/20 | 0.80 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20201860 | 0.94 | ENPP2 (0.90) | ENPP2JAK2JAK1JAK3 | |
| SCHEMBL30147021 | 0.94 | ENPP2 (0.87) | ENPP2JAK2JAK1JAK3KDM4E | |
| SCHEMBL16739435 | 0.94 | ENPP2 (0.87) | ENPP2JAK2JAK1JAK3KDM4E | |
| SCHEMBL16739506 | 0.93 | ENPP2 (0.86) | ENPP2JAK2JAK1JAK3KDM4E | |
| SCHEMBL16739509 | 0.93 | ENPP2 (0.86) | ENPP2JAK2JAK1JAK3KDM4E | |
| SCHEMBL29507651 | 0.92 | ENPP2 (0.75) | ENPP2JAK2JAK1JAK3KDM4E | |
| SCHEMBL16739508 | 0.92 | ENPP2 (0.75) | ENPP2JAK2JAK1JAK3KDM4E | |
| SCHEMBL16775405 | 0.90 | ENPP2 (0.73) | ENPP2 | |
| Cudetaxestat SCHEMBL16739453 | 0.89 | ENPP2 (1.00) | ENPP2JAK2JAK1JAK3 | |
| Cudetaxestat SCHEMBL30146949 | 0.89 | ENPP2 (1.00) | ENPP2JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180147185-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180147185-A1 | AUTOTAXIN INHIBITORS AND USES THEREOF | ENPP2, SERPINB1, RNASE1 | ENPP2 1/4885JAK2 4030/4885JAK1 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.