Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 20/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 16/20 | 0.57 |
| ▸ | OPRD1 | P41143 | 12/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187363 | 0.90 | OPRK1 (0.72) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20187338 | 0.89 | OPRK1 (0.54) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20187321 | 0.88 | OPRK1 (0.49) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202208 | 0.85 | OPRK1 (0.55) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202209 | 0.85 | OPRK1 (0.57) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202205 | 0.82 | OPRK1 (0.56) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20187332 | 0.82 | OPRK1 (0.56) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202212 | 0.82 | OPRK1 (0.56) | OPRK1OPRM1OPRD1 | |
| SCHEMBL20202207 | 0.82 | OPRK1 (0.56) | OPRK1OPRM1OPRD1 | |
| SCHEMBL30007295 | 0.82 | OPRK1 (0.56) | OPRK1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316021-B2 | Heteroarylphenoxy benzamide kappa opioid ligands | PFIZER INC. (US) | 2019-06-11 | — | — | US | disclosed |
| US-20180148432-A1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | PFIZER INC. (US) | 2018-05-31 | — | — | US | disclosed |
| WO-2018096510-A1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | PFIZER INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| US-20180148432-A1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | PFIZER INC. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10316021-B2 | Heteroarylphenoxy benzamide kappa opioid ligands | OPRK1, OPRD1, OPRM1 | OPRK1 1/4885OPRM1 3/4885OPRD1 2/4885 |
| US-20180148432-A1 | HETEROARYLPHENOXY BENZAMIDE KAPPA OPIOID LIGANDS | OPRK1, OPRD1, OPRM1 | OPRK1 1/4885OPRM1 3/4885OPRD1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.