Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | RAB9A | P51151 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.48 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31058497 | 0.92 | ALDH1A1 (0.60) | HTTLMNARAB9AMAPK1ALDH1A1 | |
| SCHEMBL16442371 | 0.91 | HTT (0.56) | HTTLMNARAB9AMAPK1ALDH1A1 | |
| Hydrochloric Acid SCHEMBL16447312 | 0.90 | MEN1 (0.56) | HTTLMNARAB9AMAPK1ALDH1A1 | |
| SCHEMBL16446727 | 0.86 | ALDH1A1 (0.56) | HTTLMNARAB9AMAPK1ALDH1A1 | |
| SCHEMBL10413533 | 0.85 | CYP1A2 (0.61) | LMNARAB9AALDH1A1PDE4BPDE4D | |
| SCHEMBL18290833 | 0.81 | EPHX2 (0.50) | HTTLMNARAB9AMAPK1 | |
| SCHEMBL31063051 | 0.81 | ALDH1A1 (0.65) | HTTLMNARAB9AMAPK1ALDH1A1 | |
| SCHEMBL6209718 | 0.80 | HSD11B1 (0.73) | HTTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL27264231 | 0.80 | PDE4D (0.56) | HTTLMNARAB9AALDH1A1PDE4B | |
| SCHEMBL21448795 | 0.79 | HSD11B1 (0.60) | LMNARAB9AALDH1A1NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148453-A1 | DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148453-A1 | DIHYDROPYRAZOLOPYRIMIDINONE COMPOUNDS AS PDE2 INHIBITORS | PDE12, PDE2A, PDE4D | HTT 98/4885LMNA 4745/4885RAB9A 700/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.