Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 12/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20187460 | 0.77 | SMN1; SMN2 (0.45) | TRPA1HDAC6 | |
| SCHEMBL20187457 | 0.72 | KDM4E (0.48) | TRPA1 | |
| SCHEMBL21363618 | 0.70 | TRPA1 (0.47) | TRPA1 | |
| SCHEMBL22477750 | 0.65 | GSK3A (0.39) | TRPA1 | |
| SCHEMBL21363471 | 0.60 | TRPA1 (0.37) | TRPA1 | |
| SCHEMBL20203315 | 0.59 | TRPA1 (0.45) | TRPA1MAPK1 | |
| SCHEMBL18964771 | 0.54 | LMNA (0.51) | — | |
| SCHEMBL31359039 | 0.54 | POLB (0.47) | HDAC6 | |
| SCHEMBL13804449 | 0.52 | TRPA1 (0.51) | TRPA1 | |
| SCHEMBL31750585 | 0.51 | MCL1 (0.47) | HDAC6MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018096159-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-31 | — | — | WO | disclosed |