Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 5/20 | 0.46 |
| ▸ | SYK | P43405 | 4/20 | 0.37 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | BRAF | P15056 | 3/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | KDM5A | P29375 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22477747 | 0.81 | TRPA1 (0.42) | TRPA1KDM5AADORA2B | |
| SCHEMBL21363531 | 0.81 | TRPA1 (0.42) | TRPA1 | |
| SCHEMBL20203287 | 0.79 | BCAT2 (0.39) | TRPA1SYKBCAT2LMNAHPGD | |
| SCHEMBL20203286 | 0.76 | TRPA1 (0.45) | TRPA1SYKBCAT2LMNAHPGD | |
| SCHEMBL23718322 | 0.73 | BCAT2 (0.35) | TRPA1SYKBCAT2LMNAHPGD | |
| SCHEMBL20187580 | 0.71 | PARP1 (0.41) | TRPA1BCAT2HPGD | |
| SCHEMBL20203176 | 0.69 | TRPA1 (0.41) | TRPA1SYKBCAT2LMNAHPGD | |
| SCHEMBL20203483 | 0.69 | TRPA1 (0.46) | TRPA1LMNADPP4ADORA2B | |
| SCHEMBL20187573 | 0.69 | DPP4 (0.37) | TRPA1LMNADPP4KDM5AADORA2B | |
| SCHEMBL20203484 | 0.66 | TRPA1 (0.47) | TRPA1SYKBCAT2LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544979-B1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-08-04 | — | — | EP | disclosed |
| WO-2019182925-A1 | OXADIAZOLE TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | GENENTECH, INC. (US) | 2019-09-26 | — | — | WO | disclosed |
| WO-2018096159-A1 | OXADIAZOLONES AS TRANSIENT RECEPTOR POTENTIAL CHANNEL INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2018-05-31 | — | — | WO | disclosed |