Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP15 | Q460N3 | 5/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 5/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.39 |
| ▸ | TLR4 | O00206 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23052782 | 0.79 | PARP15 (0.42) | PARP15PARP10TDP1SLC6A2SLC6A4 | |
| SCHEMBL21325222 | 0.79 | PARP15 (0.39) | PARP15PARP10TDP1SLC6A2SLC6A4 | |
| SCHEMBL20204753 | 0.76 | HMBS (0.37) | PARP15PARP10TDP1SLC6A2SLC6A4 | |
| SCHEMBL16727170 | 0.74 | LMNA (0.47) | PARP15PARP10TDP1SLC6A2PARP2 | |
| SCHEMBL20208335 | 0.72 | ADORA2A (0.38) | PARP15PARP10TDP1SLC6A2SLC6A4 | |
| SCHEMBL2665020 | 0.69 | PARP15 (0.55) | PARP15PARP10TDP1PARP2 | |
| SCHEMBL8930160 | 0.69 | PARP15 (0.55) | PARP15PARP10TDP1PARP2 | |
| SCHEMBL29024848 | 0.69 | PARP15 (0.64) | PARP15PARP10TDP1PARP2 | |
| SCHEMBL8221790 | 0.69 | PARP15 (0.50) | PARP15PARP10TDP1SLC6A2SLC6A4 | |
| SCHEMBL31498181 | 0.68 | SLC6A2 (0.49) | PARP15PARP10TDP1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018098209-A1 | AMINO SULFONYL COMPOUNDS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |
| WO-2018098207-A1 | HYDANTOIN CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS | CV6 THERAPEUTICS (NI) LIMITED (GB) | 2018-05-31 | — | — | WO | disclosed |