Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 4/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.48 |
| ▸ | SCD | O00767 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10264757 | 0.86 | TDO2 (0.44) | RXRAGRIN1GRIN2BSCDTDO2 | |
| SCHEMBL21478371 | 0.79 | RXRA (0.44) | RXRAGRIN1GRIN2BL3MBTL1KDM4E | |
| SCHEMBL5546869 | 0.79 | GRM4 (0.48) | TDO2L3MBTL1KDM4EMAPTMAPK1 | |
| SCHEMBL122101 | 0.76 | MTOR (0.38) | RXRAGRIN1GRIN2BTDO2L3MBTL1 | |
| SCHEMBL12349894 | 0.74 | GRM4 (0.43) | TDO2L3MBTL1KDM4EMAPTMAPK1 | |
| SCHEMBL10264239 | 0.74 | KAT6A (0.48) | RXRAGRIN1GRIN2BTDO2L3MBTL1 | |
| SCHEMBL14320344 | 0.73 | TDO2 (0.49) | SCDTDO2L3MBTL1KDM4EMAPT | |
| SCHEMBL12988811 | 0.73 | TDO2 (0.41) | TDO2L3MBTL1KDM4EMAPTMAPK1 | |
| SCHEMBL3143610 | 0.72 | NPC1 (0.50) | RXRAGRIN1GRIN2BL3MBTL1KDM4E | |
| SCHEMBL17180077 | 0.72 | CYP46A1 (0.46) | TDO2L3MBTL1KDM4EMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544613-B1 | GSK-3 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2021-06-09 | — | — | EP | disclosed |
| WO-2018098412-A1 | GSK-3 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-05-31 | — | — | WO | disclosed |