Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.46 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 4/20 | 0.45 |
| ▸ | FPR3 | P25089 | 1/20 | 0.43 |
| ▸ | FPR2 | P25090 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20068838 | 0.87 | ALDH1A1 (0.51) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL20148071 | 0.84 | ALDH1A1 (0.48) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL20070437 | 0.84 | LMNA (0.48) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL20206039 | 0.84 | LMNA (0.49) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL25505302 | 0.81 | ALDH1A1 (0.45) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL23126232 | 0.80 | RET (0.49) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL25505300 | 0.76 | POLB (0.48) | RAB9AALDH1A1NPC1LMNAKMT2A | |
| SCHEMBL29445396 | 0.73 | KMT2A (0.58) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL41767 | 0.73 | KMT2A (0.58) | RAB9AALDH1A1NPC1LMNAKDM4E | |
| SCHEMBL9019385 | 0.73 | RAB9A (0.57) | RAB9AALDH1A1NPC1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2023-05-16 | — | — | US | disclosed |
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | RAB9A 632/4885ALDH1A1 2547/4885NPC1 4145/4885 |
| US-11648243-B2 | Substituted pyrazolo[1,5-A]pyridine compounds as RET kinase inhibitors | RET, BRAF, RAF1 | RAB9A 632/4885ALDH1A1 2547/4885NPC1 4145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.