Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CARM1 | Q86X55 | 1/20 | 0.52 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | WHR1 | P49842 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25103860 | 0.91 | CARM1 (0.47) | CARM1PRMT6ALDH1A1KDM4ECCR6 | |
| SCHEMBL11447302 | 0.83 | ALDH1A1 (0.61) | CARM1PRMT6ALDH1A1CCR6WHR1 | |
| SCHEMBL4250673 | 0.82 | CARM1 (0.48) | CARM1PRMT6ALDH1A1KDM4ECCR6 | |
| SCHEMBL4250664 | 0.82 | CARM1 (0.48) | CARM1PRMT6ALDH1A1KDM4ECCR6 | |
| SCHEMBL18713202 | 0.81 | CARM1 (0.51) | CARM1PRMT6ALDH1A1KDM4ECCR6 | |
| SCHEMBL28738958 | 0.79 | CYP2D6 (0.59) | CARM1PRMT6ALDH1A1KDM4ECCR6 | |
| SCHEMBL25104611 | 0.78 | ALDH1A1 (0.55) | CARM1PRMT6ALDH1A1CCR6WHR1 | |
| SCHEMBL18741437 | 0.77 | KDM4E (0.68) | CARM1PRMT6KDM4ECCR6HRH3 | |
| SCHEMBL7500754 | 0.77 | OPRM1 (0.51) | CARM1PRMT6ALDH1A1KDM4ECCR6 | |
| SCHEMBL13558661 | 0.76 | OPRM1 (0.58) | CARM1PRMT6KDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2018-05-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180148445-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, BRAF, RAF1 | CARM1 150/4885PRMT6 133/4885ALDH1A1 2547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.