Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.51 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.51 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.48 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9523741 | 0.78 | OPRM1 (0.55) | OPRM1OPRD1OPRK1OPRL1CARM1 | |
| SCHEMBL28738958 | 0.78 | CYP2D6 (0.59) | OPRM1OPRD1OPRK1OPRL1CARM1 | |
| SCHEMBL10598753 | 0.77 | OPRM1 (0.63) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL20205982 | 0.77 | CARM1 (0.52) | CARM1PRMT6KDM4EALDH1A1CCR6 | |
| SCHEMBL7405479 | 0.76 | OPRK1 (0.52) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL11447302 | 0.76 | ALDH1A1 (0.61) | CARM1PRMT6ALDH1A1CCR6 | |
| SCHEMBL10601133 | 0.76 | CYP1A2 (0.62) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL113896 | 0.76 | CYP1A2 (0.62) | OPRM1OPRD1OPRK1OPRL1SLC6A4 | |
| SCHEMBL25103860 | 0.74 | CARM1 (0.47) | CARM1PRMT6KDM4EALDH1A1CCR6 | |
| SCHEMBL12513620 | 0.74 | MC4R (0.65) | OPRM1OPRD1OPRK1OPRL1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1265870-A1 | NEW CCR5 MODULATORS: BENZIMIDAZOLES OR BENZOTRIAZOLES | AstraZeneca AB (SE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001066525-A1 | NEW CCR5 MODULATORS: BENZIMIDAZOLES OR BENZOTRIAZOLES | ASTRAZENECA AB (SE) | 2001-09-13 | — | — | WO | disclosed |