Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.69 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.52 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL3457784 | 1.00 | GSR (0.69) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Alpha-Ketoglutaric Acid SCHEMBL393521 | 0.95 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Alpha-Ketoglutaric Acid SCHEMBL393522 | 0.95 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL2020669 | 0.92 | GSR (0.67) | GSRGRM8GRM6GRIN2DGRIN3B | |
| D-Glutamate SCHEMBL4234844 | 0.92 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL2020671 | 0.92 | GSR (0.67) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Glutamic Acid SCHEMBL4234847 | 0.92 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5246406 | 0.91 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5246411 | 0.91 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL1191629 | 0.91 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 105 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111812309-A | Urine protein marker for tumor bone metastasis and application thereof | 北京师范大学 | 2020-10-23 | — | — | CN | claimed |
| WO-2014089436-A1 | METHODS AND SYSTEMS FOR METHYLOTROPHIC PRODUCTION OF ORGANIC COMPOUNDS | GINKGO BIOWORKS, INC. (US) | 2014-06-12 | — | — | WO | claimed |
| CN-101321873-B | Transgenic plant seed with increased lysine | MONSANTO TECHNOLOGY LLC | 2013-08-14 | — | — | CN | claimed |
| WO-2013066848-A1 | METHODS AND SYSTEMS FOR CHEMOAUTOTROPHIC PRODUCTION OF ORGANIC COMPOUNDS | GINKGO BIOWORKS, INC. (US) | 2013-05-10 | — | — | WO | claimed |
| CN-102517261-A | Lysine-ketoglutarate reductase/saccharopine dehydrogenase of plant and coding gene and applications thereof | JIANGSU ACAD AGRICULTURAL SCI | 2012-06-27 | — | — | CN | claimed |
| WO-2011031285-A1 | IMPROVING ESSENTIAL AMINO ACID CONTENT IN ALGAE AND CYANOBACTERIA FOR ANIMAL FEED | UFAZ SHAI (IL) | 2011-03-17 | — | — | WO | claimed |
| US-20100260887-A1 | Content of the essential amino acids lysine and methionine in algae and cyanobacteria for improved animal feed | TRANSALGAE (IL) | 2010-10-14 | — | — | US | claimed |
| CN-101321873-A | Transgenic plant seed with increased lysine | MONSANTO TECHNOLOGY LLC (US) | 2008-12-10 | — | — | CN | claimed |
| US-20250221952-A1 | METHODS AND COMPOSITIONS FOR LARGE MODIFICATIONS OF ATP OUTPUT BY INNER MITOCHONDRIAL MEMBRANE LATCHING | DISCHLER LOUIS (US) | 2025-07-10 | — | — | US | disclosed |
| CN-118203566-A | Use of 2-aminoadipic acid to modulate inflammatory responses induced by high fat diets | 厦门大学附属翔安医院 | 2024-06-18 | — | — | CN | disclosed |
| US-11819027-B2 | Streptomyces endophyte compositions and methods for improved agronomic traits in plants | INDIGO AG, INC. (US) | 2023-11-21 | — | — | US | disclosed |
| US-11384126-B2 | Compositions and methods for inhibiting DHHC-type palmitoyltransferases for cancer treatment | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-07-12 | — | — | US | disclosed |
| EP-3957716-A1 | DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS | Janssen Biotech, Inc. (US) | 2022-02-23 | — | — | EP | disclosed |
| US-20210204505-A1 | Streptomyces Endophyte Compositions and Methods for Improved Agronomic Traits in Plants | INDIGO AGRICULTURE, INC. | 2021-07-08 | — | — | US | disclosed |
| WO-2002022675-A2 | PLANT GENES, THE EXPRESSION OF WHICH ARE ALTERED BY PATHOGEN INFECTION | SYNGENTA PARTICIPATIONS AG (CH) | 2002-03-21 | — | — | WO | disclosed |
| WO-2002016655-A2 | STRESS-REGULATED GENES OF PLANTS, TRANSGENIC PLANTS CONTAINING SAME, AND METHODS OF USE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2002-02-28 | — | — | WO | disclosed |
| WO-2001049856-A2 | DROSOPHILA ENZYMES, ENCODING NUCLEIC ACIDS AND METHODS OF USE | GENOPTERA, LLC (US) | 2001-07-12 | — | — | WO | disclosed |
| WO-2001049856-A2 | DROSOPHILA ENZYMES, ENCODING NUCLEIC ACIDS AND METHODS OF USE | GENOPTERA, LLC (US) | 2001-07-12 | — | — | WO | disclosed |
| EP-1074617-A2 | Primers for synthesising full-length cDNA and their use | Helix Research Institute (JP) | 2001-02-07 | — | — | EP | disclosed |
| CN-1253584-A | Chimeric genes and methods for increasing lysine content of seeds of plants | DU PONT (US) | 2000-05-17 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250221952-A1 | METHODS AND COMPOSITIONS FOR LARGE MODIFICATIONS OF ATP OUTPUT BY INNER MITOCHONDRIAL MEMBRANE LATCHING | SHMT2, TUFM, TFB2M | GSR 43/4885GRM8 2721/4885GRM6 2229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.