Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 2/20 | 0.69 |
| ▸ | GRM8 | O00222 | 1/20 | 0.52 |
| ▸ | GRM6 | O15303 | 1/20 | 0.52 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.52 |
| ▸ | GRM5 | P41594 | 1/20 | 0.52 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.52 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.52 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.52 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.52 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.52 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL1442876 | 1.00 | GSR (0.69) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Alpha-Ketoglutaric Acid SCHEMBL393521 | 0.95 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Alpha-Ketoglutaric Acid SCHEMBL393522 | 0.95 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL2020669 | 0.92 | GSR (0.67) | GSRGRM8GRM6GRIN2DGRIN3B | |
| D-Glutamate SCHEMBL4234844 | 0.92 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL2020671 | 0.92 | GSR (0.67) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Glutamic Acid SCHEMBL4234847 | 0.92 | GSR (0.60) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5246406 | 0.91 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL5246411 | 0.91 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B | |
| Lysine SCHEMBL1191629 | 0.91 | GSR (0.83) | GSRGRM8GRM6GRIN2DGRIN3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111812309-A | Urine protein marker for tumor bone metastasis and application thereof | 北京师范大学 | 2020-10-23 | — | — | CN | claimed |
| EP-3294757-B1 | BACTERIA ENGINEERED TO TREAT A DISEASE OR DISORDER | SYNLOGIC OPERATING CO INC (US) | 2023-12-27 | — | — | EP | disclosed |
| CN-111812309-A | Urine protein marker for tumor bone metastasis and application thereof | 北京师范大学 | 2020-10-23 | — | — | CN | disclosed |
| EP-3217807-A1 | METHODS AND COMPOSITIONS FOR EGG WHITE PROTEIN PRODUCTION | Clara Foods Co. (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2016077457-A1 | METHODS AND COMPOSITIONS FOR EGG WHITE PROTEIN PRODUCTION | CLARA FOODS CO. (US) | 2016-05-19 | — | — | WO | disclosed |
| US-20100124548-A1 | Pharmaceutical product | UNIVERSITY OF OULU (FI) | 2010-05-20 | — | — | US | disclosed |
| WO-2010049590-A2 | A NEW PHARMACEUTICAL PRODUCT | OULUN YLIOPISTO (FI) | 2010-05-06 | — | — | WO | disclosed |
| US-20090258002-A1 | Biomarkers for Tissue Status | GOVERNMENT OF THE US, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2009-10-15 | — | — | US | disclosed |
| CN-100412198-C | Method of increasing lysine content in paddy rice seed and special carrier | BEIJING KAITUO DIEN AGRICULTUR (CN) | 2008-08-20 | — | — | CN | disclosed |
| WO-2007030531-A2 | REAGENTS FOR TESTING AND MOLECULAR IMAGING OF LIVER CANCER | MOLECULAR IMAGE INC. (US) | 2007-03-15 | — | — | WO | disclosed |
| CN-1834252-A | Method of increasing lysine content in paddy rice seed and special carrier | WEIMING KAITUO AGRICULTURE & B (CN) | 2006-09-20 | — | — | CN | disclosed |
| EP-1402037-A1 | PLANT GENES INVOLVED IN DEFENSE AGAINST PATHOGENS | Syngenta Participations AG (CH) | 2004-03-31 | — | — | EP | disclosed |
| WO-2003000898-A1 | PLANT GENES INVOLVED IN DEFENSE AGAINST PATHOGENS | SYNGENTA PARTICIPATIONS AG (CH) | 2003-01-03 | — | — | WO | disclosed |