Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 5/20 | 0.65 |
| ▸ | TOP1 | P11387 | 3/20 | 0.50 |
| ▸ | TOP2A | P11388 | 3/20 | 0.50 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.50 |
| ▸ | SNCA | P37840 | 4/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20207016 | 0.87 | PTPN11 (0.49) | PTPN11TOP1TOP2ATOP2BSNCA | |
| SCHEMBL1812080 | 0.78 | TOP1 (0.81) | TOP1TOP2ATOP2BSNCAABCC1 | |
| SCHEMBL20187640 | 0.76 | PTPN11 (1.00) | PTPN11SNCA | |
| SCHEMBL20206977 | 0.73 | PTPN11 (0.71) | PTPN11 | |
| SCHEMBL28277339 | 0.72 | TOP1 (0.77) | TOP1TOP2ATOP2BSNCAABCC1 | |
| SCHEMBL11789948 | 0.71 | TOP1 (0.54) | TOP1TOP2ATOP2BPLAU | |
| SCHEMBL29381898 | 0.69 | ERN1 (0.50) | TOP1TOP2ATOP2BSNCA | |
| SCHEMBL22466044 | 0.69 | ERN1 (0.50) | TOP1TOP2ATOP2BSNCA | |
| SCHEMBL2911616 | 0.69 | HDAC2 (0.71) | PLAU | |
| SCHEMBL468884 | 0.69 | PTPN11 (0.79) | PTPN11SNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544952-B1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIV ANTWERPEN (BE) | 2024-11-06 | — | — | EP | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | UNIVERSITAIR ZIEKENHUIS ANTWERPEN (BE) | 2020-08-11 | — | — | US | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2019-09-19 | — | — | US | disclosed |
| WO-2018096088-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | UNIVERSITEIT ANTWERPEN (BE) | 2018-05-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190284130-A1 | HALOGENATED BENZOTROPOLONES AS ATG4B INHIBITORS | ATG4B, ATG7, ATG4A | PTPN11 2700/4885TOP1 2951/4885TOP2A 2831/4885 |
| US-10738002-B2 | Halogenated benzotropolones as ATG4B inhibitors | ATG4B, ATG7, BECN1 | PTPN11 2737/4885TOP1 2859/4885TOP2A 2481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.